Simon studied Molecular Cell Biology, Biochemistry and Molecular Biosciences with major Cancer Biology at Heidelberg University, Imperial College London and the German Cancer Research Center (DKFZ). He received his PhD from DKFZ and Heidelberg University in 2016. Simon performed research at DKFZ, Massachusetts Institute of Technology (MIT) and Harvard. Since 2016, he is junior group leader at HI-STEM.